{"id":525,"date":"2025-03-15T04:06:45","date_gmt":"2025-03-15T04:06:45","guid":{"rendered":"https:\/\/blogs.unpad.ac.id\/sriwidodo\/?p=525"},"modified":"2025-03-15T04:06:45","modified_gmt":"2025-03-15T04:06:45","slug":"preparation-of-mangosteen-peel-extract-microcapsules-by-fluidized-bed-spray-drying-for-tableting-improving-the-solubility-and-antioxidant-stability","status":"publish","type":"post","link":"https:\/\/blogs.unpad.ac.id\/sriwidodo\/2025\/03\/15\/preparation-of-mangosteen-peel-extract-microcapsules-by-fluidized-bed-spray-drying-for-tableting-improving-the-solubility-and-antioxidant-stability\/","title":{"rendered":"&#8220;Preparation of Mangosteen Peel Extract Microcapsules by Fluidized Bed Spray-Drying for Tableting: Improving the Solubility and Antioxidant Stability&#8221;"},"content":{"rendered":"<p data-start=\"0\" data-end=\"231\">Link artikel: https:\/\/www.mdpi.com\/2076-3921\/11\/7\/1331<\/p>\n<ol data-start=\"252\" data-end=\"1914\">\n<li data-start=\"252\" data-end=\"441\">\n<p data-start=\"255\" data-end=\"311\"><strong data-start=\"255\" data-end=\"310\">Ekstrak Kulit Manggis (Mangosteen Peel Extract\/MPE)<\/strong>:<\/p>\n<ul data-start=\"315\" data-end=\"441\">\n<li data-start=\"315\" data-end=\"360\">Mengandung senyawa fenolik tinggi (39,87%).<\/li>\n<li data-start=\"364\" data-end=\"441\">Memiliki kandungan utama \u03b1-mangostin sebesar 15,68% (sekitar 70 mg\/tablet).<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"443\" data-end=\"854\">\n<p data-start=\"446\" data-end=\"467\"><strong data-start=\"446\" data-end=\"466\">Mikroenkapsulasi<\/strong>:<\/p>\n<ul data-start=\"471\" data-end=\"854\">\n<li data-start=\"471\" data-end=\"619\">Menggunakan metode fluidized bed spray-drying dengan hidroksipropil metilselulosa (HPMC) sebagai inti dan polyvinyl alcohol (PVA) sebagai pelapis.<\/li>\n<li data-start=\"623\" data-end=\"745\">Mikroenkapsulasi berhasil meningkatkan kelarutan ekstrak kulit manggis di air dan mempertahankan stabilitas antioksidan.<\/li>\n<li data-start=\"749\" data-end=\"854\">Ukuran mikroenkapsulasi (MPEM) rata-rata 411,2 \u00b5m, berbentuk bulat dengan permukaan kasar dan berongga.<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"856\" data-end=\"1117\">\n<p data-start=\"859\" data-end=\"894\"><strong data-start=\"859\" data-end=\"893\">Karakteristik Mikroenkapsulasi<\/strong>:<\/p>\n<ul data-start=\"898\" data-end=\"1117\">\n<li data-start=\"898\" data-end=\"986\">Aliran mikroenkapsulasi awal cukup baik, namun meningkat signifikan setelah granulasi.<\/li>\n<li data-start=\"990\" data-end=\"1117\">Sifat aliran (flow rate) awal 32,46 g\/s, sudut istirahat 43,45\u00b0, indeks kompresibilitas 21,51%, dan kadar air rendah (0,74%).<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"1119\" data-end=\"1510\">\n<p data-start=\"1122\" data-end=\"1158\"><strong data-start=\"1122\" data-end=\"1157\">Karakteristik Granul dan Tablet<\/strong>:<\/p>\n<ul data-start=\"1162\" data-end=\"1510\">\n<li data-start=\"1162\" data-end=\"1237\">Formula optimal tablet mengandung PVP K30 sebagai binder 5% (formula F3).<\/li>\n<li data-start=\"1241\" data-end=\"1361\">Granul memiliki sifat aliran yang baik, indeks kompresibilitas rendah (9%), dan kehilangan kadar air terendah (1,74%).<\/li>\n<li data-start=\"1365\" data-end=\"1510\">Tablet terbaik (F3) berwarna jingga kekuningan, kekerasan tinggi (87,8 N), kerapuhan rendah (0,94%), dan waktu hancur optimal sekitar 14 menit.<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"1512\" data-end=\"1914\">\n<p data-start=\"1515\" data-end=\"1570\"><strong data-start=\"1515\" data-end=\"1569\">Stabilitas Senyawa Aktif dan Aktivitas Antioksidan<\/strong>:<\/p>\n<ul data-start=\"1574\" data-end=\"1914\">\n<li data-start=\"1574\" data-end=\"1724\">Kandungan \u03b1-mangostin stabil selama proses produksi dan penyimpanan selama satu bulan pada kondisi zona IVB (suhu 40 \u00b0C dan kelembaban relatif 75%).<\/li>\n<li data-start=\"1728\" data-end=\"1914\">Aktivitas antioksidan (IC50) juga stabil dan tidak mengalami perubahan signifikan selama proses mikroenkapsulasi hingga pembuatan tablet (IC50 ekstrak 34,64 \u00b5g\/mL; tablet 41,16 \u00b5g\/mL).<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<h3 data-start=\"1916\" data-end=\"1937\">Kesimpulan Utama:<\/h3>\n<p data-start=\"1938\" data-end=\"2217\">Mikroenkapsulasi ekstrak kulit manggis menggunakan metode fluidized bed spray-drying dengan kombinasi HPMC dan PVA efektif meningkatkan kelarutan dan mempertahankan stabilitas antioksidan ekstrak kulit manggis, baik selama proses pembuatan tablet maupun selama masa penyimpanan.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Link artikel: https:\/\/www.mdpi.com\/2076-3921\/11\/7\/1331 Ekstrak Kulit Manggis (Mangosteen Peel Extract\/MPE): Mengandung senyawa fenolik tinggi (39,87%). Memiliki kandungan utama \u03b1-mangostin sebesar 15,68%<\/p>\n","protected":false},"author":6578,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-525","post","type-post","status-publish","format-standard","hentry","category-penelitian"],"_links":{"self":[{"href":"https:\/\/blogs.unpad.ac.id\/sriwidodo\/wp-json\/wp\/v2\/posts\/525","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.unpad.ac.id\/sriwidodo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.unpad.ac.id\/sriwidodo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.unpad.ac.id\/sriwidodo\/wp-json\/wp\/v2\/users\/6578"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.unpad.ac.id\/sriwidodo\/wp-json\/wp\/v2\/comments?post=525"}],"version-history":[{"count":1,"href":"https:\/\/blogs.unpad.ac.id\/sriwidodo\/wp-json\/wp\/v2\/posts\/525\/revisions"}],"predecessor-version":[{"id":526,"href":"https:\/\/blogs.unpad.ac.id\/sriwidodo\/wp-json\/wp\/v2\/posts\/525\/revisions\/526"}],"wp:attachment":[{"href":"https:\/\/blogs.unpad.ac.id\/sriwidodo\/wp-json\/wp\/v2\/media?parent=525"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.unpad.ac.id\/sriwidodo\/wp-json\/wp\/v2\/categories?post=525"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.unpad.ac.id\/sriwidodo\/wp-json\/wp\/v2\/tags?post=525"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}